Roles of the valine clusters in domain 3 of the hemolytic lectin CEL-III in its oligomerization and hemolytic abilities.
نویسندگان
چکیده
The hemolytic lectin CEL-III and its site-directed mutants were expressed in Escherichia coli cells. Replacement of the valine clusters in domain 3 with alanine residues led to increased self-oligomerization in solution and higher hemolytic activity. The results suggest the involvement of these valine clusters in CEL-III oligomerization and hemolytic activity.
منابع مشابه
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ورودعنوان ژورنال:
- Protein and peptide letters
دوره 16 4 شماره
صفحات -
تاریخ انتشار 2009